Search Results - invasion

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Antisense Oligonucleotides against Cancer Cell Migration and Invasion
Summary: NCI is seeking parties interested in co-developing and/or licensing therapeutic antisense oligonucleotides that target cell migration and cancer metastasis. Description of Technology: Advanced stage cancers are typically marked by metastases of the primary cancer to secondary sites such as lungs, liver, and bones. Such metastatic cancers...
Published: 4/24/2026   |   Updated: 8/2/2023   |   Inventor(s): Stavroula Mili
Keywords(s): Antisense, APC, CANCER, Invasion, Metastasis, MIGRATION, Mili, Net1, OLIGO, oligonucleotide, Oncology, Rab13, RNA
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Application > Therapeutics
Targeting mDia formins to halt tumor microtube formation, invasion, and proliferation in brain tumors
Project ID D2019-34 High-grade gliomas, including glioblastoma, remain difficult to treat because invasive tumor cells can migrate away from the primary tumor mass, limiting the effectiveness of surgical resection and contributing to recurrence. These invasive cells may form long cellular projections known as tumor microtubes (TMs), which are enriched...
Published: 5/14/2026   |   Updated: 1/11/2021   |   Inventor(s): Kathryn Eisenmann, Krista Pettee, Kathryn Becker
Keywords(s): Tumor microtubes, Cancer, Formin, Glioblastoma, High-grade glioma, Invasion, mDia
Category(s): Oncology, Neuroscience