Drug-resistant infections, widespread pediatric infections such as otitis media, contaminated wounds, implant-associated infections, and airborne pathogens continue to place increasing pressure on healthcare systems. Conventional antibiotics tend to be less effective, may have systemic side effects and often do not provide targeted therapy at the site of infection. Therefore, there is a need for a flexible antibiotic-free solution for on-demand control of pathogens, while enabling safer, localized care.
A multifunctional nanoplatform with surface-stabilized metallic and semiconductor nanoparticles, fluorescent, polymer-composite, and piezoelectric elements in a single flexible system. When stimulated by light, ultrasound, airflow, movement, or mechanical stress, it generates localized Reactive Oxygen Species (ROS) that neutralize pathogens and disrupt biofilms. Its modular design can be easily converted into sprays, gels, dressings, filters and protective coatings for middle-ear infections, wound care, air purification, implant and catheter protection and targeted pathogen tracking in biomedical and environmental applications.
Image Description: Fig. 1. Multifunctional Stimuli-Activated Nanoplatform for Targeted ROS Therapy, Infection Control, and Environmental Protection.