Search Results - tengfei+he

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Programmable intracellular RNA scaffolds for integrating sensing and regulation

Co-transactionally folded RNA nanostructures in living cells. Invention Summary: Biomarker validation and intracellular RNA detection require tools that are precise, scalable, and capable of capturing complex gene expression patterns. Current approaches, including CRISPR-based systems, RNA interference, and RNA sponge technologies, are often...

Published: 5/1/2026 | Updated: 5/1/2026 | Inventor(s): Fei Zhang, Xu (leo) Chang, Jean-Pierre Etchegaray, Maciej Jeziorek

Keywords(s):

Category(s): Technology Classifications > Healthcare & Life Sciences

A Method to Treat Neurodegenerative Diseases

This innovation is a method and composition for treating, preventing, or delaying the progression of neurodegenerative diseases using cell type-specific gene therapy. The therapy is delivered to human or veterinary subjects using an adeno-associated virus (AAV) vector that carries the peroxisome proliferator-activated receptor alpha (PPARA) gene. The...

Published: 4/24/2026 | Updated: 4/15/2026 | Inventor(s): Fei Yin, Weihua Wang

Keywords(s):

Category(s): Technology Classifications > Life Sciences, Technology Classifications > Healthcare Portfolios > Neurology

Site-Specific Synthesis of 2D TMDs for High-Performance Nanoelectronic Devices

A lithographically defined, transfer-free CVD process enables site-specific growth of MoS₂ directly on CMOS-compatible SiO₂/Si substrates using patterned MoO₃ as both precursor and high-k dielectric. The approach delivers tunable crystallinity, improved interface quality, and enhanced FET performance while eliminating post-growth transfer and etching...

Published: 4/16/2026 | Updated: 3/3/2026 | Inventor(s): Huamin Li, Fei Yao, Gabriel Lee, Keith Wong, Ajay Yadav, Chu-Te Chen, Anthony Cabanillas

Keywords(s): Materials & Chemicals, Semiconductor and Microprocessing, Technologies

Category(s): Campus > University at Buffalo, Technology Classifications > Electronics, Technology Classifications > Nanotechnology, Technology Classifications > Materials and Chemicals

Energy Efficient Steep Slope Cold Electron DIRAC Transistor

Graphene-enabled Dirac-source "cold" electron transistor breaks the sub-60 mV/decade threshold and achieves current density over 1µA/µm Background: Power dissipation and energy efficiency in electronics are huge barriers facing the explosive growth of artificial intelligence (AI) and high-performance computing (HPC). Metal-oxide-semiconductor...

Published: 4/16/2026 | Updated: 10/2/2025 | Inventor(s): Huamin Li, Fei Yao

Keywords(s): Technologies

Category(s): Campus > University at Buffalo, Technology Classifications > Energy Conservation, Technology Classifications > Nanotechnology, Technology Classifications > Electronics, Technology Classifications > Quantum Computing

SonicSurf Manipulator

THE CHALLENGE Developing advanced contactless manipulation technologies lies in creating a solution that is not only technically effective but also scalable, affordable, and easy to integrate into real-world biomedical and chemical workflows. Current methods—like optical tweezers, magnetic actuators, and traditional acoustic systems—are...

Published: 6/25/2025 | Updated: 5/13/2025 | Inventor(s): Zhenhua Tian, Teng Li, Jiali Li, Luyu Bo

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Category(s): Technology Classifications > Biomedical, Technology Classifications > Chemicals/Materials, Technology Classifications > Engineering

Allopregnanolone (ALLO), the Pregnancy Neuro-Steroid, is Neuroprotective in Hypoxic-Ischemic Injury of the Immature Brain

This innovation focuses on the potential therapeutic use of Allopregnanolone (ALLO), a natural neurosteroid, to treat hypoxic ischemic (HI) brain injury in premature infants. ALLO, naturally produced in the placenta during brain development, is absent in premature infants, which contributes to the neurological deficits observed in HI cases. The proposed...

Published: 11/21/2025 | Updated: 4/2/2025 | Inventor(s): Roberta Brinton, Nahla Zaghloul, Mohamed Ahmed, Akash Gupta, Tian Wang, Fei Yin

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Pediatrics, Technology Classifications > Life Sciences > Therapeutics

Sensitive Point-of-Care miRNA Detection Using a One-Pot, Isothermal Assay

Rapid, RNA Extraction-Free Detection of miRNAs Biomarkers for Accurate Cancer Diagnosis and Prognosis This CRISPR-Cas12a-based assay allows for the rapid, sensitive detection of microRNAs using a one-pot, isothermal process. MicroRNAs(miRNAs) are endogenous and short, non-coding single-stranded RNAs. They participate in various biological functions...

Published: 1/20/2026 | Updated: 3/4/2025 | Inventor(s): Yong Zeng, He Yan

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Category(s): Technology Classifications > Human Health Care > Diagnostics, Technology Classifications > Veterinary > Diagnostics

Wireless Surface Acoustic Wave Sensor System for Multi-Parameter Monitoring

THE CHALLENGE: Wireless sensing technologies play a crucial role in various sectors, including structural health monitoring, environmental surveillance, healthcare, and industrial automation. Surface acoustic wave (SAW) sensors, leveraging the piezoelectric effect, are particularly valued for their ability to detect multiple physical parameters such...

Published: 10/27/2025 | Updated: 12/4/2024 | Inventor(s): Zhenhua Tian, Luyu Bo, Jiali Li, Teng Li

Keywords(s):

Category(s): Technology Classifications > Electronics

Wireless Acoustofluidic System for Remote Manipulation of Nanoparticles and Cells

THE CHALLENGE: Acoustofluidics, the integration of acoustic waves with microfluidic systems, plays a crucial role in manipulating particles and cells for applications in biomedical research, diagnostics, and lab-on-a-chip technologies. This technology enables precise control over fluid flow, particle concentration, and cell alignment without physical...

Published: 10/27/2025 | Updated: 12/4/2024 | Inventor(s): Zhenhua Tian, Jiali Li, Luyu Bo, Teng Li

Keywords(s):

Category(s): Technology Classifications > Biomedical

Robot-Assisted Acoustic Tweezers

THE CHALLENGE Contactless manipulation of objects is a critical need in various fields, particularly in biomedical applications where non-invasive techniques are essential. Traditional methods often require direct contact with the objects being manipulated, which can lead to unwanted disturbances or damage, especially when dealing with delicate biological...

Published: 6/26/2025 | Updated: 12/4/2024 | Inventor(s): Zhenhua Tian, Teng Li, Jiali Li, Luyu Bo

Keywords(s):

Category(s): Technology Classifications > Robotics

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