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Multipronged Composite Protocol for High-Efficiency Deep Tissue RNA Delivery and Expression

An RNA transfection and protein expression approach comprising lipid nanoparticles, hyaluronic acid, and photostimulation Problem: As the field of cell modification has expanded, researchers have sought more effective methods for nucleic acid (NA) delivery into cells. RNA transfection is easier to facilitate and control than DNA transfection, making...

Published: 5/13/2026 | Updated: 5/13/2026 | Inventor(s): James Eberwine, Jai-Yoon Sul, Hyunbum Kim

Keywords(s): Cell Therapy, Gene Editing, Gene Therapy, Platform Technology, Protein/Peptide (Non-Antibody)

Category(s): Technology Classifications > Medical Devices, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics

Northwestern Startup: Akava Therapeutics

Founded: 2019 Northwestern Inventor: Richard Silverman Weinberg College of Arts and Sciences Department of Chemistry and Department of Molecular Biosciences Feinberg School of Medicine Department of Pharmacology AKAVA Therapeutics is developing first-in-class small molecule therapeutics that inhibit enzymes, inhibit cancer, and inhibit protein...

Published: 5/13/2026 | Updated: 5/13/2026 | Inventor(s):

Keywords(s): ALS - Amyotrophic Lateral Sclerosis, Neurodegenerative disease, Neurology, Therapeutics

Category(s): Medical

Tibial Tubercle Osteotomy Fixation Device

Fixation device to secure bone fragment of tibial tuberosity to native bone after osteotomy surgical procedure. Background: Standard osteotomy techniques to join the tibial tubercle fragment to native bone include screw fixation alone or fixation with wire or suture, which are not reliable methods to holding the bone in place to avoid displacement...

Published: 5/13/2026 | Updated: 5/13/2026 | Inventor(s): Timothy Damron

Keywords(s): biomedical, biomedical engineering, hardware, healthcare, instrumentation, medical devices, medical equipment, orthopedics, osteoarthritis, surgery, suturing technique, Technologies

Category(s): Technology Classifications > Medical Devices, Campus > Upstate Medical University

Increasing Efficiency of Anti-Tumor Immune Checkpoint Blockade Therapy by Manipulating Tumor-Associated Macrophages

A method to manipulate tumor-associated macrophages by targeting the mitochondrial electron transport chain, improving the efficacy of immune checkpoint blockade cancer therapies. Problem: Many cancer therapeutics work by activating the immune system to attack a tumor. These drugs, known as immune checkpoint blockade (ICB) therapies, commonly fail because...

Published: 5/13/2026 | Updated: 5/13/2026 | Inventor(s): Jorge Henao-Mejia, Megan Clark

Keywords(s): Drug Target, Immunology, Oncology

Category(s): Technology Classifications > Therapeutics

Coatings containing polar additives and their use as ice shedding surfaces.

This invention relates to advanced polyurea-siloxane (PU) coatings modified with natural deep eutectic solvents (NADES) and co-curing additives to improve ice-shedding performance under real-world conditions. The coating system incorporates choline chloride-glycerol NADES into a moisture-curable polymer matrix, enabling the formation of microphase-separated...

Published: 5/13/2026 | Updated: 5/13/2026 | Inventor(s): Dean Webster, Geetisubhra Jena, Olena Shafranska, Emma Nissen

Keywords(s): Anti-icing; Ice Shedding

Category(s): Technologies, Technologies > Chemistry & Materials, Technologies > Paints & Coatings

'ND Redvelvet' small red bean (NDF151006-2)

‘ND Redvelvet’ small red bean was released in 2026 by the North Dakota Agricultural Experiment Station. Developed from the cross SR9-4/'Rio Rojo', ND Redvelvet has demonstrated competitive agronomic performance compared to other small red varieties commonly grown in the region. It matures in approximately 101 days and offers improved...

Published: 5/13/2026 | Updated: 5/13/2026 | Inventor(s): Juan Osorno

Keywords(s): Agriculture, Plants

Category(s): Technologies > Agricultural Varieties, Technologies > Agricultural Varieties > Dry Beans

Multifunctional Fluoropolymer Composite Films and Methods of Preparing the Same

This technology involves the development of multifunctional PVDF-based composite films incorporating two commercial alumina nanoparticle grades—SpectrAl® 81 and SpectrAl® 51—and recycled micronized ground tire rubber (GTR). The films are fabricated using a scalable solution-casting process in which PVDF and selected filler compositions...

Published: 5/13/2026 | Updated: 5/13/2026 | Inventor(s): Marcel Roy Domalanta, Eugene Caldona

Keywords(s): Composites, Paints & Coatings

Category(s): Technologies, Technologies > Chemistry & Materials, Technologies > Paints & Coatings

'ND Pink-Slipper' light red kidney bean (ND151660)

Released in 2026 by the North Dakota Agricultural Experiment Station, ‘ND Pink-Slipper’ light red kidney (LRK) bean combines strong agronomic performance with excellent seed quality. Originating from the cross 'Clouseau'/'Rosie', it has performed competitively with other LRK varieties commonly grown in the region while maturing...

Published: 5/13/2026 | Updated: 5/13/2026 | Inventor(s): Juan Osorno

Keywords(s): Agriculture, Plants

Category(s): Technologies > Agricultural Varieties, Technologies > Agricultural Varieties > Dry Beans

Epigenetic Gene Editing in Cardiomyopathy to Improve Heart Function

SHORT DESCRIPTION A precision cardiac gene‑regulation platform that deletes a MYH7 enhancer to shift ventricular myosin isoform balance toward faster α‑MHC and activates upstream MYH6 enhancers to increase MYH6 expression and improve contractility, creating a dual toolkit for disease‑modifying therapy in cardiomyopathy and heart failure. INVENTORS Elizabeth...

Published: 5/13/2026 | Updated: 5/12/2026 | Inventor(s):

Keywords(s): Cardiology and Cardiovascular disease, Cardiomyopathy, Gene therapy, Regenerative medicine, Therapeutics

Category(s): Life Sciences > Therapeutics

Delivery of exogenous protein/peptide cargoes to the cell cytosol

Survival curves of weanling mice immunized with LFn-LACV-Gc or LFn-LACV-N compared with LFn-ZIKV-NS3 and subsequently challenged with LACV Invention Summary: Novel T cell-based vaccine was developed by utilizing a fusion protein by binding a target protein or peptide molecule with transport factor derived from Bacteria. The target protein...

Published: 5/12/2026 | Updated: 5/12/2026 | Inventor(s): Bobby Brooke Herrera

Keywords(s):

Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Vaccine

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