Search Results - ramiro+iglesias-bartolome

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A Novel Genetically Encoded Inhibitor of Hippo Signaling Pathway to Study YAP1/TAZ-TEAD Dependent Events in Cancer
Summary: The NCI Laboratory of Cellular and Molecular Biology seeks statements of capability or interest from parties interested in licensing this novel inhibitor of the Hippo signaling pathway. Description of Technology: The Hippo signaling pathway regulates a multitude of biological processes including cell proliferation, apoptosis, differentiation,...
Published: 4/24/2026   |   Updated: 8/2/2023   |   Inventor(s): Ramiro Iglesias-Bartolome, Yao Yuan
Keywords(s): Cancer Progression, Hippo Signaling Pathway, Iglesias-Bartolome, Peptide Inhibitor, TAZ, TEAD, YAP1, Yes-Associated Protein 1
Category(s): TherapeuticArea > Oncology, Application > Research Materials, Collaboration Sought > Licensing
mTOR Inhibition for the Prevention of Epithelial Stem Cell Loss and Mucositis
The integrity of the epidermis and mucosal epithelia is highly dependent on self-renewing stem cells and, therefore, is vulnerable to physical and chemical damage from common cancer treatments, such as radiation or chemotherapy. Consequently, many cancer patients undergoing these treatments develop mucositis, a debilitating condition involving painful...
Published: 12/26/2024   |   Updated: 12/6/2022   |   Inventor(s): Ramiro Iglesias-Bartolome, Vyomesh Patel, Ana Cotrim, Alfredo Molinolo, James Mitchell, J Silvio Gutkind
Keywords(s): CBXXXX, Cell, CXXXXX, Epithelial, inhibition, mTOR, Mucositis, PREVENTS, PROTECTS, Radiation-induced, Senescence, Stem
Category(s): Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Licensing