Search Results - life+sciences+%3e+therapeutics

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Epigenetic Gene Editing in Cardiomyopathy to Improve Heart Function
SHORT DESCRIPTION A precision cardiac gene‑regulation platform that deletes a MYH7 enhancer to shift ventricular myosin isoform balance toward faster α‑MHC and activates upstream MYH6 enhancers to increase MYH6 expression and improve contractility, creating a dual toolkit for disease‑modifying therapy in cardiomyopathy and heart failure. INVENTORS Elizabeth...
Published: 5/12/2026   |   Updated: 5/12/2026   |   Inventor(s):  
Keywords(s): Cardiology and Cardiovascular disease, Cardiomyopathy, Gene therapy, Regenerative medicine, Therapeutics
Category(s): Life Sciences > Therapeutics
Targeted Nanoparticle-Mediated HIF Stabilization in Myeloid Cells for Enhanced Transplant Tolerance
SHORT DESCRIPTION A PEG-PPS nanoparticle technology for targeted delivery of roxadustat to myeloid cells to promote transplantation tolerance. INVENTORS Edward Thorp* Northwestern University Feinberg School of Medicine, Department of Pathology Evan Scott* McCormick School of Engineering, Department...
Published: 5/7/2026   |   Updated: 5/7/2026   |   Inventor(s):  
Keywords(s): Drug delivery, Immunotherapy, Nanoparticle, Therapeutics, Tolerance induction, Transplantation
Category(s): Life Sciences > Therapeutics
Targeting Autoimmunity-Associated T cells via AHR Pathway Control
SHORT DESCRIPTION Use of AHR agonists to inhibit pathogenic Tfh/Tph cell differentiation, potentially reducing disease activity. INVENTORS Jaehyuk Choi* Northwestern University Feinberg School of Medicine, Department of Dermatology **(Now at UT Southwestern)** Deepak Rao Brigham and Women's...
Published: 5/7/2026   |   Updated: 5/7/2026   |   Inventor(s):  
Keywords(s): Autoimmune disease, Immunology, Immunotherapy, Inflammation, RA - Rheumatoid arthritis, SLE - Systemic lupus erythematosus, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
Antisense Oligonucleotides to Prevent Genetic Mis-Splicing for ALS/FTD Therapeutics
SHORT DESCRIPTION Antisense oligonucleotides (ASOs) that correct TDP‑43–dependent mis‑splicing of KCNQ2 thereby reducing neuronal hyperexcitability in ALS/FTD and related TDP‑43 proteinopathies. INVENTORS Evangelos Kiskinis* Northwestern University Feinberg School of Medicine, Department of Neurology Jonathan...
Published: 5/12/2026   |   Updated: 5/7/2026   |   Inventor(s):  
Keywords(s): ALS - Amyotrophic Lateral Sclerosis, FTD - Frontotemporal Dementia, Neurodegenerative disease, Neurologic disease, Neurology, Nucleic Acids, Rare diseases, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
Incomplete Autophagy Induction for the Treatment of Cancer
SHORT DESCRIPTION This incomplete autophagy inducer triggers caspase-mediated apoptosis in cancer cells by inducing incomplete autophagy, leading to tumor reduction and improved survival. INVENTORS INVENTORS Maciej Lesniak* Northwestern University Feinberg School of Medicine, Department of Neurological Surgery Jawad...
Published: 5/7/2026   |   Updated: 5/7/2026   |   Inventor(s):  
Keywords(s): Brain cancer, Breast cancer, Cancer/Oncology, Lung cancer, Melanoma, Repurposed Drugs, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
Once-Weekly Glucocorticoid Steroid Dosing for Enhanced Muscle Function and Metabolic Health
SHORT DESCRIPTION A glucocorticoid regimen that preserves the benefits of steroids on muscle mass and function while mitigating many of the metabolic and growth‑related toxicities seen with daily dosing in various inflammatory, autoimmune, respiratory, and neuromuscular disease settings. INVENTORS Elizabeth McNally*, MD, PhD Northwestern...
Published: 5/11/2026   |   Updated: 5/7/2026   |   Inventor(s):  
Keywords(s): Aging, DMD - Duchenne muscular dystrophy, Immunology, Inflammation, Metabolic disorders, Muscle metabolism, Rare diseases, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
Northwestern Startup: Acumen Pharmaceuticals, Inc.
Founded: 1996 Northwestern Inventor: William Klein Weinberg College of Arts and Sciences Department of Neurobiology and Physiology Grant Krafft Feinberg School of Medicine Department of Molecular Pharmacology and Biological Chemistry Acumen Pharmaceuticals develops therapeutics for Alzheimer's Disease (AD) based upon the discovery and characterization...
Published: 5/7/2026   |   Updated: 5/7/2026   |   Inventor(s):  
Keywords(s): Antibody, Neurodegenerative disease, Neurologic disease, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Healthcare Devices, Tools & IT
Northwestern Startup: Syenex, Inc.
Northwestern Inventor: Joshua Leonard McCormick School of Engineering Chemical and Biological Engineering Syenex builds bioengineering technologies to unlock the future of human health. Leveraging the power of synthetic biology, we design scalable, precision-engineered components, empowering cell and gene therapy developers to cure disease and build...
Published: 5/5/2026   |   Updated: 5/5/2026   |   Inventor(s):  
Keywords(s): Biologic, Biomedical, Drug delivery, Gene therapy, Platform technology, Research tool, Startup with Northwestern IP, Synthetic biology, Therapeutics, Vector/Plasmid
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Therapeutics
Northwestern Startup: Yobee Care, Inc.
Founded: 2018 Northwestern Inventor: Dr. Ruchi Gupta Feinberg School of Medicine Department of Pediatrics and Medicine Yobee's mission is to revolutionize scalp, hair, and skin care by helping consumers rebalance their microbiome and eliminating the need for chemical-laden products. Utilizing PROBYOME , our patented blend of probiotic extracts,...
Published: 5/5/2026   |   Updated: 5/5/2026   |   Inventor(s):  
Keywords(s): Dermatology, Hair care, Scalp care, Skin care, Startup with Northwestern IP, Therapeutics
Category(s): Life Sciences > Therapeutics
GDNF-Mimetic Self-Assembling Supramolecular Nanostructure to Enhance Survival and Function of Dopaminergic Neurons for Treatment of Parkinson's Disease
NU 2024-175 SHORT DESCRIPTION A self-assembling bioactive matrix that presents GDNF-mimetic peptides to support the viability, maturation, and function of dopaminergic neurons in cell replacement therapy for treatment of Parkinson’s Disease. INVENTORS Samuel Stupp* Weinberg College of Arts and Sciences, Department...
Published: 5/11/2026   |   Updated: 4/30/2026   |   Inventor(s):  
Keywords(s): Biologic, Biomaterials, Cell delivery, CNS - Central Nervous System, CVA - Cerebrovascular Accident, Nanomaterials, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease, Scaffold, SCI - Spinal cord injury, TBI - Traumatic brain injury, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Healthcare Devices, Tools & IT > Neurology
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