Search Results - hugh+smyth

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Eliminates variable oral bioavailability: Intranasal levothyroxine powder delivers 2x mucosal permeation. This technology is a stable, intranasal dry powder formulation of levothyroxine free acid designed to improve absorption and avoid degradation, offering a more reliable alternative to oral thyroid hormone therapy for hypothyroidism. Background Hypothyroidism...

Published: 5/12/2026 | Updated: 5/12/2026 | Inventor(s): Hugh Smyth, Nila Murali, Matthew Herpin, Eldina Memic

Keywords(s):

Category(s): Life sciences > Therapeutics > Formulation

Simvastatin In-Situ Gel

Thermoresponsive nanoscale intranasal delivery system for enhancing direct nose-to-brain drug delivery This technology is an intranasal gel spray that uses nanoscale simvastatin particles and mucoadhesive, thermoresponsive gel to improve brain drug delivery, increase nasal retention, and bypass first-pass metabolism for better treatment of neurological...

Published: 5/12/2026 | Updated: 5/12/2026 | Inventor(s): Hugh Smyth, Jailen Doyle, Molly Levine

Keywords(s):

Category(s): Life sciences > Therapeutics > Formulation

Bifunctional fusion protein for biofilm degradation and quorum sensing disruption

Background Bacterial biofilms pose a major challenge in clinical and industrial environments due to their dense extracellular matrix and heightened tolerance to antibiotics and immune responses. Infections involving biofilms, particularly those caused by Pseudomonas aeruginosa, are difficult to eradicate and contribute to chronic wounds, persistent...

Published: 1/30/2026 | Updated: 1/30/2026 | Inventor(s): Hugh Smyth, Tom Smisek, Rex Moore, Nila Murali, John Schroeder, Walter Fast

Keywords(s):

Category(s): Life sciences > Therapeutics > Biologic

Spray-dried RNA-lipid nanoparticle dry powder technology for stable and inhalable delivery of therapeutics

Background Messenger RNA (mRNA) therapeutics have rapidly emerged as a transformative method for vaccination and gene therapy. However, the field faces significant hurdles related to the instability of mRNA molecules, which are highly susceptible to enzymatic degradation. Lipid nanoparticles (LNPs) have become the delivery vehicle of choice, shielding...

Published: 1/27/2026 | Updated: 1/27/2026 | Inventor(s): Zhengrong Cui, Bhupendra Giri, Hugh Smyth

Keywords(s):

Category(s): Life sciences > Therapeutics > Manufacturing platform, Life sciences > Therapeutics > Formulation

Dual-action topical formulations for enhanced skin penetration and targeted dermal repair

Background Dermatological and cosmetic treatments increasingly focus on targeted delivery of active compounds to the deeper skin layers to combat photoaging, oxidative damage, and carcinogenesis. However, the stratum corneum presents a formidable barrier to percutaneous absorption, limiting the efficacy of topically applied actives. Conventional...

Published: 1/13/2026 | Updated: 8/14/2025 | Inventor(s): Hugh Smyth, Patricia Martins

Keywords(s):

Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Therapeutics > Drug delivery

High-dose dry powder inhaler for dual pulmonary and oral indomethacin delivery

Background Dry powder inhalers (DPIs) offer a non-invasive and rapid route for drug delivery, particularly for medications requiring swift systemic action. This is especially relevant for poorly soluble drugs such as indomethacin, where oral administration is often limited by gastrointestinal degradation and adverse side effects. For indications...

Published: 1/13/2026 | Updated: 8/14/2025 | Inventor(s): Hugh Smyth, Jamie Spahn, Feng Zhang

Keywords(s):

Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Therapeutics > Drug delivery

Inhalable vancomycin–DNase powder for eradication of MRSA lung infections

Background Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital-acquired pneumonia, contributing to elevated mortality, prolonged hospitalizations, and increased healthcare costs. The persistence of MRSA in the lungs is largely due to its ability to form biofilms and generate persister cells, both of which protect the bacteria...

Published: 1/13/2026 | Updated: 8/14/2025 | Inventor(s): Hugh Smyth, Rex Moore

Keywords(s):

Category(s): Life sciences > Therapeutics > Formulation

Optimized inhalation formulation of clofazimine and amikacin for targeted treatment of respiratory infections

The invention describes a pharmaceutical composition combining clofazimine and amikacin for inhalation to treat respiratory diseases like tuberculosis. This formulation enhances drug delivery to the lungs, improving efficacy and reducing systemic side effects. Background Bacterial infections, particularly those caused by mycobacteria such as Mycobacterium...

Published: 1/13/2026 | Updated: 10/15/2024 | Inventor(s): Hugh Smyth, Ashlee Brunaugh

Keywords(s):

Category(s): Life sciences > Therapeutics > Manufacturing platform

Advanced nanoparticle delivery system for targeted pulmonary administration of therapeutic nucleic acids

Lipid nanoparticles (LNPs) are designed for delivering RNA to lung tissues via inhalation. Composed of ionizable lipids, phospholipids, PEG-lipids, and cholesterol, they encapsulate RNA for therapeutic or immunological purposes, maintaining stability during nebulization. Background Gene therapy and editing hold significant promise for treating genetic...

Published: 1/13/2026 | Updated: 10/15/2024 | Inventor(s): Hugh Smyth, Hairui Zhang, Robert Williams

Keywords(s):

Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Therapeutics > Drug delivery

Individualized intranasal delivery system for direct pharmaceutical administration to the brain

The technology involves a customizable nasal delivery device for precise administration of medications directly to the brain, bypassing traditional barriers. It uses imaging techniques for optimal placement, enhancing drug delivery efficiency and minimizing systemic side effects. Background Oral administration remains the predominant method for drug...

Published: 1/13/2026 | Updated: 10/11/2024 | Inventor(s): Hugh Smyth, Robert Williams, Zachary Warnken, Yang Lu

Keywords(s):

Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Medical technology > Medical devices

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