Search Results - andreas+matouschek

2 Results Sort By:
Modular protein degradation platform bypassing ubiquitination
Background Targeted protein degradation is rapidly emerging as a powerful therapeutic approach for eliminating disease-causing proteins in cancer, neuro­degenera­tive conditions, autoimmune disorders, and viral infections. By removing, rather than inhibiting, harmful proteins, this strategy enables direct and sustained therapeutic effects....
Published: 1/13/2026   |   Updated: 7/31/2025   |   Inventor(s): Andreas Matouschek, Amit Gautam, Caroline Davis, Logan Spaller
Keywords(s):  
Category(s): Life sciences > Therapeutics > Synthetic biology, Life sciences > Research tools > Tool/assay/screening platform
Degradons: target proteins for degradation without ubiquitination
This technology uses engineered proteins called degradons to selectively bind and degrade disease-related proteins, offering a targeted approach for treating diseases. Background The field of targeted molecular therapeutics focuses on neutralizing pathogenic proteins responsible for severe diseases, including cancer and neurodegenerative disorders....
Published: 6/4/2026   |   Updated: 1/9/2024   |   Inventor(s): Andreas Matouschek
Keywords(s):  
Category(s): Life sciences > Research tools, Life sciences > Metabolic engineering