Search Results - therapeutics+%3e+immunology+and+immunotherapy

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Enhanced Therapeutic Effect of Armored CAR-T Cells for the Treatment of Glioblastoma (UCLA Case No. 2024-066)

UCLA researchers from the Department of Microbiology, Immunology, and Molecular Genetics have engineered chimeric antigen receptor (CAR)-T cells that co-express defined immunostimulatory cytokines to enhance therapeutic efficiency against glioblastoma (GBM). BACKGROUND: Glioblastoma Multiforme (GBM) is the most common primary malignant brain tumor...

Published: 5/1/2026 | Updated: 5/1/2026 | Inventor(s): Yvonne Chen

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > CNS and Neurology

Active Electromagnetic Interference Suppression for Magnetic Resonance Imaging-Guided Interventions (Case No. 2026-217)

Summary: UCLA researchers in the Department of Radiological Sciences have developed a software-based active electromagnetic interference suppression solution for real-time MRI-guided interventions. Background: Microwave ablation (MWA) has emerged as the preferred thermal ablation modality for treating non-surgical patients with primary and metastatic...

Published: 4/16/2026 | Updated: 4/14/2026 | Inventor(s): Holden Wu, Qing Dai

Keywords(s):

Category(s): Software & Algorithms, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Image Processing, Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > MRI, Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Lab Equipment, Medical Devices > Monitoring And Recording Systems, Therapeutics, Therapeutics > CNS and Neurology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Inflammation And Inflammatory Diseases, Mechanical, Mechanical > Instrumentation, Mechanical > Sensors, Electrical, Electrical > Electronics & Semiconductors, Electrical > Signal Processing, Electrical > Instrumentation, Electrical > Imaging

Gene-Modified Conventional Type 1 Dendritic Cells (UCLA Case No. 2026-093)

Details available soon. Please contact UCLA Technology Development Group if you have any questions or would like more information in the meantime.

Published: 5/9/2026 | Updated: 3/4/2026 | Inventor(s): Steven Dubinett

Keywords(s):

Category(s): Therapeutics > Immunology And Immunotherapy

Microbial Regulation of Immune Tolerance and Risk for Cancer (UCLA Case No. 2026-153)

Details available soon. Please contact UCLA Technology Development Group if you have any questions or would like more information in the meantime.

Published: 5/9/2026 | Updated: 3/4/2026 | Inventor(s): Elaine Hsiao

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

TCR-Dependent Exhaustion Signature and Blockade of HNF1B to Overcome T Cell Exhaustion for Cancer Immunotherapy (UCLA Case No. 2026-249)

Details available soon. Please contact UCLA Technology Development Group if you have any questions or would like more information in the meantime.

Published: 4/29/2026 | Updated: 3/4/2026 | Inventor(s): Cristina Puig Saus

Keywords(s):

Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy

Partial Transcription Factor Reprogramming to Rejuvenate Exhausted Tumor-Specific T Cells into Stem-Like Memory T Cells (UCLA Case No. 2024-240)

UCLA researchers from the Department of Surgery have developed a novel approach to partially reprogram exhausted tumor-infiltrating T cells into stem-like memory T cells capable of durable tumor elimination. BACKGROUND: Adoptive cell therapies, such as tumor-infiltrating lymphocyte (TIL) therapy involve isolating T cells from a patient’s tumor,...

Published: 4/1/2026 | Updated: 3/4/2026 | Inventor(s): Tyler McCaw, Joseph Crompton

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Stem Cells And Regenerative Medicine, Life Science Research Tools > Research Methods

Compositions and Methods to Modulate MAVS-Mediated Immunity (UCLA Case No. 2026-096)

UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have developed methods to target TOM70, a mitochondrial outer membrane protein, to selectively modulate innate immune signaling and control pathological or protective immune responses across a range of clinical conditions. BACKGROUND: Innate immune detection of viral...

Published: 2/18/2026 | Updated: 2/18/2026 | Inventor(s): Lena Pernas

Keywords(s):

Category(s): Diagnostic Markers > Targets And Assays, Diagnostic Markers > Immunology, Diagnostic Markers > Cancer, Platforms > Diagnostic Platform Technologies, Therapeutics > Oncology, Therapeutics > Infectious Diseases, Therapeutics > Immunology And Immunotherapy, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Autoimmune, Therapeutics > Vaccines

Regulated Gene Expression During Differentiation of Mature T Cells (UCLA Case No. 2022-147)

UCLA researchers from the Department of Pathology & Laboratory Medicine have developed a process to genetically modify stem cells to express transgenes in a regulated, stage-specific manner, avoiding the negative consequences of transgene expression during T cell development. Contact UCLA Technology Development Group for more information.

Published: 1/27/2026 | Updated: 1/27/2026 | Inventor(s): Gay Crooks, Donald Kohn

Keywords(s):

Category(s): Therapeutics > Gene Therapy And Editing, Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Inflammation And Inflammatory Diseases

Enhancing T Cell Production in Vitro From Stem and Progenitor Cells (UCLA Case No. 2022-257)

UCLA researchers from the Department of Pathology and Laboratory Medicine have developed an innovative differentiation method to increase T cell production for T cell immunotherapy. Contact UCLA Technology Development Group for more information.

Published: 1/27/2026 | Updated: 1/27/2026 | Inventor(s): Gay Crooks, Christopher Seet

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

Peri-Operative Cancer Therapy to Preserve Anti-Tumor Immune Surveillance (UCLA Case No. 2025-257)

UCLA Researchers from the Department of Surgery have developed a novel approach to preserve anti-tumor immunity in the peri-operative period through modulation of clinically relevant molecular and cellular targets. BACKGROUND: Surgical resection with curative intent is a mainstay of treatment for many solid tumors. However, even when the tumor is macroscopically...

Published: 2/4/2026 | Updated: 1/12/2026 | Inventor(s): Tyler McCaw, Joseph Crompton

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy

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