Search Results - therapeutics+%3e+autoimmune

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Engineered Gamma Delta T-Cells and Methods of Making and Using Thereof (UCLA Case No. 2020-913)
UCLA researchers in the Department of Molecular Immunology & Molecular Genetics have developed gamma delta (gd) T cell receptor gene-modified immune cells derived from stem and progenitor cells that enable scalable, off-the-shelf allogeneic cell therapies with broad therapeutic potential. BACKGROUND: Cell-based immunotherapies have demonstrated...
Published: 3/4/2026   |   Updated: 3/4/2026   |   Inventor(s): Lili Yang, Derek Lee, Tyler Halladay
Keywords(s):  
Category(s): Diagnostic Markers > Immunology, Diagnostic Markers > Cancer, Life Science Research Tools > Cell Lines, Therapeutics > Oncology, Therapeutics > CNS and Neurology, Therapeutics > Hematology, Therapeutics > Autoimmune, Therapeutics > Gene Therapy And Editing, Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Infectious Diseases
Compositions and Methods to Modulate MAVS-Mediated Immunity (UCLA Case No. 2026-096)
UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have developed methods to target TOM70, a mitochondrial outer membrane protein, to selectively modulate innate immune signaling and control pathological or protective immune responses across a range of clinical conditions. BACKGROUND: Innate immune detection of viral...
Published: 2/18/2026   |   Updated: 2/18/2026   |   Inventor(s): Lena Pernas
Keywords(s):  
Category(s): Diagnostic Markers > Targets And Assays, Diagnostic Markers > Immunology, Diagnostic Markers > Cancer, Platforms > Diagnostic Platform Technologies, Therapeutics > Oncology, Therapeutics > Infectious Diseases, Therapeutics > Immunology And Immunotherapy, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Autoimmune, Therapeutics > Vaccines
Highly Selective Targeting of Interleukin 12 P40 Gene Expression for the Treatment of Autoimmune Diseases (UCLA Case No. 2020-864)
UCLA researchers from the Department of Microbiology, Immunology and Molecular Genetics have identified key inhibitors and inhibitory pathways targeting a pro- inflammatory molecule implicated in a vast array of autoinflammatory diseases. BACKGROUND: Inflammatory autoimmune diseases are a broad group of disorders of the immune system where the body...
Published: 10/22/2025   |   Updated: 10/3/2025   |   Inventor(s): Stephen Smale
Keywords(s):  
Category(s): Therapeutics > Autoimmune, Therapeutics > Dermatology, Therapeutics > Inflammation And Inflammatory Diseases
A Glucose-Responsive Glucagon-Micelle for the Prevention of Hypoglycemia (UCLA Case No. 2024-161)
UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel glucose-responsive drug delivery system that enables the controlled release of glucagon for the prevention of hypoglycemia. BACKGROUND: Diabetes is a metabolic disorder in which the body cannot properly regulate blood sugar levels due to the loss of insulin-producing...
Published: 5/11/2026   |   Updated: 10/2/2025   |   Inventor(s): Heather Maynard, Daniele Vinciguerra, Andrea Hevener, Jane Yang, Rajalakshmi Pallathery Sivasankaran, Panagiotis Georgiou, Katherine Snell, Kathryn Messina
Keywords(s):  
Category(s): Platforms > Drug Delivery, Therapeutics > Metabolism And Endocrinology, Therapeutics > Autoimmune, Chemical > Chemical Sensors, Chemical > Polymers, Materials > Nanotechnology
Engineered Mucosal-Associated Invariant T (MAIT) Cells and Methods of Making and Using Thereof (UCLA Case No. 2024-055)
UCLA researchers in the Department of Microbiology Immunology and Molecular Genetics have developed a novel platform and methodology for the production of mucosal-associated invariant T (MAIT) cells for therapeutic use in infectious diseases, autoimmune disorders, and cancer. BACKGROUND: Mucosal-associated invariant T (MAIT) cells are a subset of...
Published: 7/31/2025   |   Updated: 7/31/2025   |   Inventor(s): Lili Yang
Keywords(s):  
Category(s): Therapeutics > Oncology, Therapeutics > Infectious Diseases, Therapeutics > Immunology And Immunotherapy, Therapeutics > Autoimmune
Hemodynamics Driven Magnetoelastic Vascular Graft (Case No. 2025-124)
Summary: UCLA researchers in the Department of Bioengineering have developed a novel magnetoelastic vascular graft to provide real-time, wireless, and continuous stenosis monitoring. TITLE: Hemodynamics Driven Magnetoelastic Vascular Graft Background: Vascular grafts are commonly used to restore blood flow in patients with blocked or damaged blood...
Published: 4/24/2026   |   Updated: 6/10/2025   |   Inventor(s): Jun Chen, Song Li, Guorui Chen
Keywords(s): cardiovascular monitoring, Diagnostic Platform Technologies (E.G. Microfluidics), hemodynamic monitoring, Hemodynamics, magnetoelastic sensor, Medical diagnostics, Vascular therapy
Category(s): Diagnostic Markers > Immunology, Life Science Research Tools > Screening Libraries, Medical Devices > Monitoring And Recording Systems, Therapeutics > Autoimmune, Therapeutics > Immunology And Immunotherapy, Therapeutics > Transplant, Therapeutics > Hematology, Therapeutics > Cardiovascular
Saliva Anti-SSA/Ro IgA1 Differentiates Sjögren’s from Non-Sjögren’s Syndrome Patients (UCLA Case No. 2023-292)
UCLA researchers in the Department of Dentistry have developed a novel methodology to accurately differentiate patients with Sjögren’s Disease from non-Sjögren’s Disease patients by monitoring saliva IgA1 forms, enabling more accurate tracking of disease progression. BACKGROUND: The presence and detection of autoantibodies within...
Published: 7/17/2025   |   Updated: 3/14/2025   |   Inventor(s): David Wong
Keywords(s):  
Category(s): Therapeutics > Autoimmune, Diagnostic Markers > Targets And Assays, Diagnostic Markers > Immunology, Therapeutics > Ophthalmology
Identifying Desirable T Lymphocytes by Change in Mass Responses (Case No. 2013-183)
Summary: UCLA researchers from the Department of Pathology and Lab Medicine have developed a novel method for the identification of T lymphocytes using live cell interferometry Background: The identification of T cell receptors (TCRs) that are specific to antigens is crucial for advancing various immunotherapies. Existing methods of characterizing...
Published: 7/17/2025   |   Updated: 7/12/2024   |   Inventor(s): Michael Teitell, Owen Witte, Thomas Zangle, Daina Burnes Linton
Keywords(s):  
Category(s): Therapeutics, Therapeutics > Immunology And Immunotherapy, Therapeutics > Autoimmune, Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Lab Equipment
A novel ER beta ligand prodrug to treat neurodegenerative conditions (UCLA Case No. 2017-168)
Researchers from the Department of Neurology and the Department of Chemistry and Biochemistry at UCLA have developed a novel ERβ ligand prodrug that is structurally designed to confer neuroprotection in neurodegenerative conditions (multiple sclerosis, Alzheimer’s disease, and cognitive deficits of menopause in otherwise healthy women). BACKGROUND: Multiple...
Published: 3/2/2026   |   Updated: 1/24/2024   |   Inventor(s): Rhonda Voskuhl, Michael Jung
Keywords(s): Autoimmune, Cns, Therapeutics & Vaccines
Category(s): Therapeutics > CNS and Neurology, Therapeutics > Autoimmune, Therapeutics, Therapeutics > Women's Health
2019-839 Self-Modulating T Cells with Robust Anti-Tumor Efficacy and Reduced Propensity for Triggering Severe Cytokine Release Syndrome
SUMMARY: Researchers from UCLA’s Department of Microbiology, Immunology and Molecular Genetics have developed methods for generating self-modulating CAR-T cells which retain robust anti-tumor function whilst having reduced adverse side effects relating to cytokine release syndrome. BACKGROUND: The immunotherapy approach of T-cell engineering...
Published: 2/12/2026   |   Updated: 1/24/2023   |   Inventor(s): Yvonne Chen
Keywords(s):  
Category(s): Therapeutics, Therapeutics > Oncology, Therapeutics > Autoimmune, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy
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