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RPGR Gene Therapy for Retinitis Pigmentosa
The National Eye Institute (NEI) seeks research co-development partners and/or licensees for the development of RPGR gene therapy for Retinitis Pigmentosa. This technology includes an abbreviated version of the RPGR gene that is effective in gene replacement therapy for treating X-linked Retinitis Pigmentosa (XLRP). This condition is a genetic disorder...
Published: 6/18/2026   |   Updated: 6/16/2026   |   Inventor(s): Michael Sandberg, Basil Pawlyk, Xinhua Shu, Robin Ali, Alan Wright, Tiansen Li
Keywords(s):  
Category(s): Application > Therapeutics, Application > Research Materials, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, ResearchProducts > Plasmids/Vectors, ResearchProducts > Sequences, ResearchProducts > Virus/Bacteria, TherapeuticArea > Ophthalmology, TherapeuticArea > Rare/Neglected Diseases
Adaptive Reinforcement Learning for Soft Exosuit
Invention Description Soft exosuits have the potential to improve mobility and reduce physical strain during walking, but providing effective assistance across different users and walking conditions remains challenging. Traditional learning control systems often require extensive tuning, large amounts of training data, or simulation environments that...
Published: 5/27/2026   |   Updated: 5/27/2026   |   Inventor(s): Jennie Si, Wenlong Zhang, Junmin Zhong, Emiliano Quinones Yumbla, Seyed Soltanian
Keywords(s):  
Category(s): Artificial Intelligence/Machine Learning, Computing & Information Technology, Human Augmentation, Physical Science
Autonomous Smart Buildings with AI and Blockchain
THE CHALLENGE Modern buildings operate at the intersection of rising operational costs, complex stakeholder demands, and increasing expectations for energy efficiency and user experience, yet most current solutions fall short of delivering a viable business model for true autonomy. Centralized building management systems often function as opaque control...
Published: 5/21/2026   |   Updated: 3/26/2026   |   Inventor(s): Alireza Shojaei, Reachsak Ly
Keywords(s):  
Category(s): Technology Classifications > Architecture/Building, Technology Classifications > Computer Science
AI-Powered Smart Building Management
THE CHALLENGE Modern smart building solutions face a critical operational bottleneck due to their reliance on rigid, rule-based automation and cloud-dependent AI platforms. These systems often struggle to adapt to changing environmental conditions or complex occupant behaviors, resulting in inefficiencies in energy management, comfort optimization,...
Published: 3/26/2026   |   Updated: 3/26/2026   |   Inventor(s): Alireza Shojaei, Reachsak Ly
Keywords(s):  
Category(s): Technology Classifications > Computer Science, Technology Classifications > Architecture/Building
Systems and Methods for Concurrent Biochemical Immunoassay and Cellular Traction Force Measurement in Hydrogels
This invention relates to a platform that couples bead-based immunoassays with 3D traction force microscopy (TFM) within a single hydrogel substrate to quantify time-resolved biochemical cues and cell-generated mechanical forces at matched locations. This invention allows researchers to directly test how local molecular cues influence cell mechanics...
Published: 6/17/2026   |   Updated: 3/23/2026   |   Inventor(s): Alex McGhee, Kelvin Pond, A Departmental Work
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics > Sensors and Detection, Technology Classifications > Engineering & Physical Sciences > Photonics, Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Research Tools > Screening assays
Silk-Chromophore Composite Materials for In Situ Oxygen Sensing
Silk-based Materials for Oxygen Sensing (T002586) Background Monitoring tissue oxygenation in vivo is critical for wound healing, organ transplants, and oncology. However, current sensors face two major hurdles: Most sensors require secondary surgery for removal, increasing patient risk and healthcare costs. Traditional materials can trigger...
Published: 3/13/2026   |   Updated: 3/13/2026   |   Inventor(s): David Kaplan, Thomas Falcucci, Kayla Presley, Jack Ly, Matthew Dalton, Tod Grusenmeyer
Keywords(s):  
Category(s): Device, Diagnostic, Nanotechnology: sensors
Dark Eye Harvester
This invention involves using an insulated light-proof chamber that allows the harvesting of eyes or another light-sensitive biomaterial without light exposure, allowing visual rhodopsin to regenerate more efficiently. The chamber has a cylindrical shape and is attached to a chest cooler with handles on top to rotate the walls. The chamber has multiple...
Published: 6/17/2026   |   Updated: 2/9/2026   |   Inventor(s): A Departmental Work, Michael Brown
Keywords(s):  
Category(s): Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation, Technology Classifications > Research Tools
Decentralized Excitable Integral Reinforcement Learning (dEIRL) for Hypersonic Vehicles
Continuous-time reinforcement learning (CT-RL) algorithms hold great promise in real-world control applications. Adaptive dynamic programming (ADP)-based CT-RL algorithms, especially their theoretical developments, have achieved great successes. However, these methods have not been demonstrated for solving realistic or meaningful learning control problems....
Published: 2/26/2026   |   Updated: 9/19/2025   |   Inventor(s): Brent Wallace, Jennie Si
Keywords(s):  
Category(s): Applied Technologies, Artificial Intelligence/Machine Learning, Computing & Information Technology, Intelligence & Security, Physical Science
Excitable Integral Reinforcement Learning (EIRL)
This algorithm is developed in the field of control systems for control of affine nonlinear continuous time (CT) systems, which include important application areas such as robotics and autonomous systems, aerospace, manufacturing, and process control. This invention falls under the class of continuous-time reinforcement learning (CT-RL) control algorithms....
Published: 2/26/2026   |   Updated: 9/12/2025   |   Inventor(s): Jennie Si, Brent Wallace
Keywords(s):  
Category(s): Artificial Intelligence/Machine Learning, Physical Science, Applied Technologies, Computing & Information Technology, Intelligence & Security
Proximity Algorithms for ECT Reconstruction
Enables high-quality emission computers tomography (ECT) whild reducing the patient's radiation exposure. BackgroundEmission computed tomography (ECT) is an important scientific and medical imaging technique. Clinical applications of ECT include detecting, staging and monitoring response to cancer therapy; detection and risk stratification of...
Published: 1/29/2026   |   Updated: 5/13/2025   |   Inventor(s): Andrzej Krol, Yuesheng Xu, Si Li, Lixin Shen
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Medical Imaging
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